Fringe proteins modulate Notch-ligand cis and trans interactions to specify signaling states
The Notch signaling pathway consists of multiple types of receptors and ligands, whose interactions can color charm wella 050 be tuned by Fringe glycosyltransferases.A major challenge is to determine how these components control the specificity and directionality of Notch signaling in developmental contexts.Here, we analyzed same-cell (cis) Notch-l